Our research

Research and development is a key part of the success of the Midlands Orthopaedic Centre.

It is how we obtain new knowledge and how we obtain new treatments to ensure we provide the best possible patient care using the latest evidence based techniques.

Evidence suggests that patients who receive treatment in organisations that participate in active research have better clinical outcomes.

Publications

• Arshad F, Hanif U, Arshad A, et al. (2021) Orthopaedic Trauma Theatre Efficiency in the COVID-19 Pandemic: Are We Returning to Normality?. Cureus 13(2): e13221. https://doi.org/10.7759/cureus.13221
• Chaudhry, F.A., Symes, T. (2021) Computer-Navigated Total Knee Replacement with GRAFTJACKET (Allograft) to Improve Patella Tracking in Osteoarthritic Valgus Knee with Chronic Patella Dislocation. SN Compr. Clin. Med. https://doi.org/10.1007/s42399-021-00737-2
• Ghani, R., Hutt, J., Mitchell, P., Granger, L., & Sandiford, N. A. (2020). Serial C-reactive Protein Monitoring in Prosthetic Joint Infection: A Powerful Predictor or Potentially Pointless?. Cureus, 12(2), e6967. https://doi.org/10.7759/cureus.6967
• Ghani, R., Usman, M., Salar, O., Khan, A. M., Karim, J., Davis, E. T., Quraishi, S., & Ahmed, M. (2019). Unplanned Clinic Attendance, Readmission, and Reoperation in the First 12 Months Postoperatively Following Hip Hemiarthroplasty for Acute Hip Fractures: Who Is At Risk?. Cureus, 11(11), e6128. https://doi.org/10.7759/cureus.6128
• Salar, O., Crosswell, S., Ghani, R., Rao, P., Meyer, C., Hay, S., Ford, D., Mangham, C., & Cool, P. (2019). Excised Femoral Heads in Hip Fracture Patients: Is Osteoporosis Worse Than Cancer?. Cureus, 11(12), e6455. https://doi.org/10.7759/cureus.6455
• Chaudhry, F. A., Ismail, S. Z., & Davis, E. T. (2018). A new system of computer-assisted navigation leading to reduction in operating time in uncemented total hip replacement in a matched population. European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 28(4), 645–648. https://doi.org/10.1007/s00590-018-2133-y
• Karim, J. S., Reynolds, J., Salar, O., Davis, E. T., Quraishi, S., & Ahmed, M. (2018). Home, No Follow-Up: Are we ignoring the significance of unplanned clinic attendances, re-admission and mortality in the first 12 months post-operatively in over 65 year olds' hip fractures treated with DHS fixation?. Injury, 49(3), 662–666. https://doi.org/10.1016/j.injury.2018.01.007
• Chaudhry F. A. (2017). Effectiveness of dry needling and high-volume image-guided injection in the management of chronic mid-portion Achilles tendinopathy in adult population: a literature review. European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 27(4), 441–448. https://doi.org/10.1007/s00590-017-1957-1
• Gandhi, M. J., Freitas, D., Lewis, M., Bolton, L., Bhasin, S., Leonard, D., & Marsh, A. (2014). Who should answer the question: "Can I drive with this plaster cast?". The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland, 12(1), 26–31. https://doi.org/10.1016/j.surge.2013.05.006
• Pagkalos, J., Chaudary, M. I., & Davis, E. T. (2014). Navigating the reaming of the acetabular cavity in total hip arthroplasty: does it improve implantation accuracy?. The Journal of arthroplasty, 29(9), 1749–1752. https://doi.org/10.1016/j.arth.2014.03.038
• Boutefnouchet, T., Bentayeb, M., Qadri, Q., & Ali, S. (2013). Long-term outcomes following single-bundle transtibial arthroscopic posterior cruciate ligament reconstruction. International orthopaedics, 37(2), 337–343. https://doi.org/10.1007/s00264-012-1609-3
• Sajid, S., Fawdington, R., & Sinha, M. (2012). Locking plates for displaced fractures of the lateral end of clavicle: Potential pitfalls. International journal of shoulder surgery, 6(4), 126–129. https://doi.org/10.4103/0973-6042.106226
• Arnaout, F., & Butt, S. (2011). Fracture of ossified Achilles tendon. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 16(2), 233. https://pubmed.ncbi.nlm.nih.gov/22091238/
• Boutefnouchet T. (2011). A simple technique to maximise eye protection for surgeons with prescription glasses. Annals of the Royal College of Surgeons of England, 93(5), 421. https://doi.org/10.1308/003588411x582717l
• Khattak, M. J., Syed, S., & Lakdawala, R. H. (2010). Operative management of unstable thoracolumbar burst fractures. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 20(5), 347–349. https://pubmed.ncbi.nlm.nih.gov/20642934/
• Ali, M. S., Higgins, G. A., & Mohamed, M. (2007). Intermediate results of Buechel Pappas unconstrained uncemented total ankle replacement for osteoarthritis. The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons, 46(1), 16–20. https://doi.org/10.1053/j.jfas.2006.10.005
• Anand, S., & Butt, M. S. (2007). Patients' response to facet joint injection. Acta orthopaedica Belgica, 73(2), 230–233.https://pubmed.ncbi.nlm.nih.gov/17515236/
• Anjum, S. N., & Butt, M. S. (2005). Treatment of comminuted proximal humerus fractures with shoulder hemiarthroplasty in elderly patients. Acta orthopaedica Belgica, 71(4), 388–395. https://pubmed.ncbi.nlm.nih.gov/16184991/
• Bassi, R. S., & Kumar, B. A. (2003). Superior dislocation of the patella; a case report and review of the literature. Emergency medicine journal : EMJ, 20(1), 97–98. https://doi.org/10.1136/emj.20.1.97
• Anjum, S. N., Faisal, M., & Butt, M. S. (2002). Avascular necrosis with complete resorption of the proximal humerus following undisplaced three-part fracture. Orthopedics, 25(11), 1288–1289. https://pubmed.ncbi.nlm.nih.gov/12452349/
• Abbas, D., Faisal, M., & Butt, M. S. (2000). Unreamed femoral nailing. Injury, 31(9), 711–717. https://doi.org/10.1016/s0020-1383(00)00077-2
• Bhagia, S. M., & Ali, M. S. (2000). Bankart operation for recurrent anterior dislocation of the shoulder using suture anchor. Orthopedics, 23(6), 589–591. https://pubmed.ncbi.nlm.nih.gov/10875420/
• Kumar, A., Jasani, V., & Butt, M. S. (2000). Management of distal femoral fractures in elderly patients using retrograde titanium supracondylar nails. Injury, 31(3), 169–173. https://doi.org/10.1016/s0020-1383(99)00275-2
• Kumar, A., & Ahmed, M. (1999). Closed reduction of posterior dislocation of the elbow: a simple technique. Journal of orthopaedic trauma, 13(1), 58–59. https://doi.org/10.1097/00005131-199901000-00014
• Kumar, A., & Shoaib, M. (1998). Unilateral sclerosis of upper femur. Postgraduate medical journal, 74(875), 553–555. https://doi.org/10.1136/pgmj.74.875.553
• Sgouros, S., & Ali, M. S. (1992). An unusual cause of carpal tunnel syndrome. Case report. Scandinavian journal of plastic and reconstructive surgery and hand surgery, 26(3), 335–337. https://doi.org/10.3109/02844319209015281

Directors of research

Specialty nurses

R&D office

Specialty recruitment figures

Study title	Project description	Target	% of target
Can Shoulder Arthroscopy Work (CSAW)	A randomised controlled trial that compared Arthoscopic Subacromial Decompression against an investigational shoulder arthroscopy (without spur removal/decompression) to indicate whether spur removal was really necessary and in turn, assessing the effectiveness of the ASAD procedure. Both surgical interventions are routine and mirrored each other except for the spur removal element. Both treatments were compared against a control (non-operative management with specialist reassessment) group to indicate whether surgery in general was effective for patients with sub-acromial pain. Patients randomised to either of the surgical options were blinded to the type of surgery received.	5	480%
INTEREST	Intervention to reduce sitting time in older adults undergoing orthopaedic surgery. To assess the feasibility of a study to reduce sitting time in older adults >= 65 year undergoing orthopaedic surgery. The main outcome was feasibility, assessed with study statistics and by using a questionnaire at baseline, pre-surgery, and 6 weeks post-surgery.	45	77.78%
Adipokines in Osteoarthritis	Investigating the role of adipokines in osteoarthritis (OA) by investigating the molecular mechanisms by which the adipokines impact on OA cartilage and bone remodelling in order to identify key targets for potential therapuetic intervention.	70	322.86%
ASCRIBED	The impact of acute systematic inflammation upon cerebrospinal fluid and blood biomarkers of brain inflammation and injury in dementia: a study in acute hip fracture patients	10	470%
Wellframe Validation Study	To assess the utility of using patient reported outcome measurement information system (PROMIS) computer adaptive tests (CATs) by assessing outcomes in subjects receiving TKA via PROMIS CAT physical function, pain interference, and depression domains and by validating these against the gold standard of the Oxford knee score.	10	180%
CCRN 778 (Process Implant Versus Surgical Decompression) MINUTEMAN	Efficacy and quality of life following treatment of lumbar spinal stenosis, spondylolisthesis or degenerative disc disease with minuteman interspinous interlinear fusion implant versus surgical decompression: a prospective randomised trial	24	66.67%

Open recruiting T&O studies

Study title	Project description	Target	% of target
HUSH Trial	A two phased multi-centre prospective randomised trial which will compare non-surgical treatment of humeral shaft fractures with surgical management. The outcomes will be pain, function and quality of life and the trial will also compare the cost-effectiveness of the two treatments.
Joint Pain and Inflammation in Osteoarthritis	To determine whether specific synovitis-associated lncRNAs are localised to areas of synovial tissue associated with OA pain. Whether these lncRNAs are associated with greater pain intensity. Whether modulating their activity mitigates the production of pain mediators and alleviates pain.	41	104.88%
Muscle and Fat Cross Talk	The role of muscle and fat cross talk in joint damage. To examine the interaction, also called cross talk, between muscle, fat, and joint tissue from patients undergoing orthopaedic surgery in order to identify new targets for therapeutic intervention.	400	9%